This book showcases examples of how inquiry-based teaching and learning (IBTL) is delivered in learning sessions with children ages three to eight. IBTL is a pedagogy that encourages students to learn by exploring, investigating, analyzing and asking questions. The practice helps hone the learner’s critical thinking, creativity and imagination. The study looks at the various factors contributing to IBTL, such as national and school-based policies, learning materials, learning environment, parental engagement, teacher preparation, assessment, and monitoring and evaluation. It also probes into how inquiry-based teaching and learning helps foster the natural state of inquisitiveness and creativity of young learners. The study offers several real-life examples of IBTL as practiced in some schools in selected Southeast Asian countries. It is hoped that these examples can serve as models that can be replicated or adapted to support development of 21st century skills which are critical in gearing up young learners in Southeast Asia for the Fourth Industrial Revolution and increasing regional and global integration.