SEAMEO Congress 2021, which was held on 28–29 April 2021, was a virtual conference attended by more than 15,000 participants from across Southeast Asia and beyond. Focusing on the theme, “Transforming Southeast Asian Education, Science, and Culture in the Digital Age,” the participants listened to discussions and presentations in five plenary sessions, four parallel sessions, two marketplace sessions, several SEAMEO regional centre presentations, and 10 teaching and learning innovation and research sessions. The congress attendees also witnessed the launch of two of SEAMEO’s newest regional centres—SEAMEO STEM-ED and SEAMEO SEPS—during the opening ceremony.